Effects Of Supplementation Of Nursery Diets With An Essentail Fatty Acid On Immunity In Artifically Reared Pigs

Kansas State University Swine Reserach. Twenty four pigs were weaned immediately at farrowing, reared artificially for 21 d, and then used in a 35-d nursery experiment to determine the effects of essential fatty acid deficiency on function. Treatments were: 1) a semi- purified diet deficient in essential fatty acids and 2) diet 1 with 2% added linoleic acid. Conver- sion of linoleic acid to linolenic and then arachidonic acid is a normal step in fatty acid metabolism. Metabolites of arachidonic acid are thought to have a role in mediating immune function. On d 28 of the experiment, pigs were orally dosed with Salmonella choleraesuis to challenge their immune systems. At d 35, pigs fed linoleic acid had greater concentrations of several fatty acids in both small intestine and liver tissues. Also, several measures of arachidonic acid metabolites in the plasma, which activate inflammatory reactions and stimulate white blood cell activity, were greater for pigs fed diets with added linoleic acid. However, no gross lesions were noted at necrop- sy that would result from infection with S. choleraesuis. Thus, for the short period of this (35 d), deficiency of essential fatty acids apparently had minimal effect on ability of nursery pigs to resist disease.